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Practice Makes Plasticity: Exploring the Impact of Motor Training on Brain Plasticity

Practice Makes Plasticity: Exploring the Impact of Motor Training on Brain Plasticity


Let's start by understanding the basics - practice makes perfect! Motor skill training involves learning and refining new movement sequences, which can lead to structural and functional changes in the brain. For instance, studies have shown that practicing a specific motor task can expand the cortical representation of the practiced body part, ultimately enhancing performance. This phenomenon has been observed in both animals and humans, indicating the remarkable adaptability of the brain in response to motor learning.

Musicians and Athletes: The Brain's Response to Intensive Motor Training

Now, let's talk about musicians and athletes. These two groups undergo rigorous motor training through the practice of their respective skills. Research has revealed that experienced musicians and athletes exhibit distinct structural and functional differences in their brains compared to non-musicians and non-athletes. For example, brain responses to specific stimuli have been found to be more pronounced in musicians, with similar findings in athletes, suggesting a heightened neural response due to their extensive training.

The Role of Plasticity-Inducing Interventions

But here's where it gets even more interesting. Scientists have been exploring whether the brains of musicians and athletes respond differently to plasticity-inducing interventions, such as repetitive transcranial magnetic stimulation (rTMS), compared to those without extensive motor training. In a recent study, researchers evaluated the effects of a plasticity-inducing protocol involving 10-Hz rTMS in combination with D-cycloserine (DCS, a drug traditionally used as an antibiotic, but which also has effects on the neurotransmitter GABA) on both musicians/athletes and non-musicians/non-athletes.

Research Findings

The study found that while musicians and athletes did not exhibit higher baseline corticomotor excitability, the plasticity-inducing protocol (10-Hz rTMS combined with DCS) significantly enhanced motor-evoked potentials (MEPs) in musicians and athletes, compared to non-musicians and non-athletes. This suggests that extensive motor practice and learning create a neuronal environment that is more responsive to plasticity-inducing events, such as rTMS. These findings shed light on the brain's remarkable adaptability in response to intensive motor training.

Understanding the Methods

Now, let's take a quick look at the methods used in the study. The researchers analyzed results from a randomized, double-blind, crossover study involving healthy adults. The participants received a single dose of either D-cycloserine or a placebo, followed by the rTMS plasticity protocol. The study utilized various measures, including motor-evoked potentials (MEPs), to assess the impact of the plasticity-inducing interventions on the participants.

Implications and Future Directions

So, what do these findings mean for our understanding of brain plasticity and motor skill learning? Well, they have significant implications for learning paradigms, such as psychotherapy and rehabilitation. By facilitating activation of key brain networks, including recovery from neurological and mental disorders, the greater capacity for plasticity observed in musicians and athletes opens up new possibilities for enhancing learning and recovery processes.


In conclusion, the relationship between motor skill learning and brain plasticity is a fascinating area of research that continues to unveil the remarkable adaptability of the human brain. The findings from this study provide valuable insights into the differential responses of the brain to plasticity-inducing interventions, shedding light on the unique neural adaptations resulting from intensive motor training.

Alright, folks, that's a wrap for today's exploration of the brain and motor skill learning. I hope you found this journey through neuroscience as intriguing as I did. Until next time, keep those neurons firing and stay curious!

Citation: Jamie Kweon et al., “Practice Makes Plasticity: 10-Hz RTMS Enhances LTP-like Plasticity in Musicians and Athletes,” Frontiers in Neural Circuits 17 (2023),


  • Brain Plasticity: Brain plasticity refers to the brain's ability to reorganize itself by forming new neural connections throughout life, especially in response to learning, experience, or injury.

  • Cortical Representation: Cortical representation refers to the specific area of the brain's cortex that is responsible for processing and controlling a particular body part or function.

  • Neuroplasticity: (neural plasticity) Ability of mature nerves and neurons to adapt their functional and morphological characteristics to environmental influences, such as during learning or compensation after loss. (

  • Neural Adaptations: Neural adaptations refer to the changes in the structure and function of the nervous system in response to stimuli or experiences, such as motor training.

  • Motor evoked potential: An electrical potential recorded from a muscle following direct stimulation of the motor cortex, often used to assess the functionality of motor pathways.